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KMID : 0363620070280040136
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 4 p.136 ~ p.147
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The Anti-obesity Effects of Gambi-hwan Extract on Obese Rats Induced by High-fat Diet through the Expression of UCP-1 and PPAR-δ
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Lee Beom-Joon
Ryu Jae-Hwan
Kim Jae-Wan
Park Jong-Hun
Park Jae-Woo
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Abstract
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Objective : Recently there are a lot of attempts to treat obesity through energy expenditure. Especially UCP-1 and PPAR- is known to play a key role for energy dissipation through the increasing thermogenesis. Gambi-hwan extract is a traditional medicine made of herbs containing the polyunsaturate fatty acids related to the energy expenditure. It is expected to reduce the weight by means of the expression of UCP-1 and PPAR-.
Meterial and Method : We divided 21 rats into 3 groups and assigned 8 rats respectively. The normal group was administered normal diet, the control group was administered high-fat diet, and the G50 group was administered high-fat diet with Gambi-hwan extracts50 mg/kg. And then the weights of body, food intake, the changes of lipids in blood stream, and the expressions of UCP-1 and PPAR- on adipose tissues were measured respectively.
Result : The reduction of body weight and the increasing tendency of expression of UCP-1 and PPAR- mRNA were shown in G50 group. In the G50 group the Triglyceride level is decreased and the HDL-cholesterol level and the expression of PPAR- and UCP-1 protein on Visceral adipose tissue were significantly increased.
Conclusion : This result indicates that Gambi-hwan Extract upregulate the expression of UCP-1 and PPAR- in adipose tissue, which may contribute to reducing the weight of adipose tissue.
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KEYWORD
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Antiobesity, UCP, PPAR, Croton tiglium, buthus martensi karsch
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